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Genetic diversity of HLA system in two populations from San Luis Potosí, Mexico: San Luis Potosí City and rural San Luis Potosí

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Hernández-Zaragoza, D. I., Rodríguez-Munguía, T. J., Barquera, R., Adalid-Sáinz, C., Arrieta-Bolaños, E., Clayton, S., et al. (2020). Genetic diversity of HLA system in two populations from San Luis Potosí, Mexico: San Luis Potosí City and rural San Luis Potosí. Human Immunology, 81(9), 528-530. doi:10.1016/j.humimm.2019.07.291.


Cite as: http://hdl.handle.net/21.11116/0000-0007-2F9D-5
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 117 Mexicans from the state of San Luis Potosí living in the city of San Luis Potosí (N = 30) and rural communities (N = 87), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state include 13 Native American, six European, two African and two Asian haplotypes. Admixture estimates revealed that the main genetic components are Native American (52.72 ± 0.66 by ML; 48.29 of Native American haplotypes) and European (34.62 ± 4.28 by ML; 32.48 of European haplotypes), and a relatively high African genetic component (12.66 ± 4.61 by ML; 10.26 of African haplotypes).