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Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Ponnendai-Shanmugavel,  Komathi Sree
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Immel,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Barquera, R., Juárez-Nicolás, F., Martínez-Álvarez, J. C., Ponnendai-Shanmugavel, K. S., Hernández-Zaragoza, D. I., Vázquez-Castillo, T. V., et al. (2020). Genetic diversity of HLA system in two populations from Chiapas, Mexico: Tuxtla Gutiérrez and rural Chiapas. Human Immunology, 81(9), 563-565. doi:10.1016/j.humimm.2019.07.285.


Cite as: http://hdl.handle.net/21.11116/0000-0007-2F38-7
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 173 Mexicans from the state of Chiapas living in the city of Tuxtla Gutiérrez (N = 52) and rural communities (N = 121), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Chiapas include 12 Native American and one European haplotype. Admixture estimates revealed that the main genetic components in Chiapas are Native American (71.61 ± 0.58 by ML; 53.16 of Native American haplotypes) and European (26.39 ± 5.05 by ML; 25.86 of European haplotypes), and a less prominent African genetic component (2.00 ± 5.20 by ML; 9.77 of African haplotypes).