English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Genetic diversity of HLA system in two populations from Tlaxcala, Mexico: Tlaxcala city and rural Tlaxcala

MPS-Authors
/persons/resource/persons214002

Barquera,  Rodrigo       
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons202721

Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

de Pavón-Vargas, M. l. Á., Crawford, M. H., Barquera, R., López-Gil, C., Arrieta-Bolaños, E., Clayton, S., et al. (2020). Genetic diversity of HLA system in two populations from Tlaxcala, Mexico: Tlaxcala city and rural Tlaxcala. Human Immunology, 81(9), 544-546. doi:10.1016/j.humimm.2019.07.282.


Cite as: https://hdl.handle.net/21.11116/0000-0007-2F54-7
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1011 Mexicans from the state of Tlaxcala residing in the city of Tlaxcala (N = 181) and rural communities (N = 830), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in Tlaxcala are all of Native American origin. Admixture estimates revealed that the main genetic components are Native American (75.13 ± 1.56 by ML; 69.24 based on of Native American haplotypes) and European (16.10 ± 4.98 by ML; 19.74 of European haplotypes), with a less prominent African genetic component (8.78 ± 4.09 by ML; 4.35 of African haplotypes).