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Processing temporal growth factor patterns by an epidermal growth factor receptor network dynamically established in space

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Koseska,  Aneta
Lise Meitner Group Cellular Computations and Learning, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Bastiaens,  Philippe I. H.
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Koseska, A., & Bastiaens, P. I. H. (2020). Processing temporal growth factor patterns by an epidermal growth factor receptor network dynamically established in space. Annual Review of Cell and Developmental Biology, 36, 359-383. doi:10.1146/annurev-cellbio-013020-103810.


Cite as: http://hdl.handle.net/21.11116/0000-0007-3359-C
Abstract
The proto-oncogenic epidermal growth factor (EGF) receptor (EGFR) is a tyrosine kinase whose sensitivity and response to growth factor signals that vary over time and space determine cellular behavior within a developing tissue. The molecular reorganization of the receptors on the plasma membrane and the enzyme-kinetic mechanisms of phosphorylation are key determinants that couple growth factor binding to EGFR signaling. To enable signal initiation and termination while simultaneously accounting for suppression of aberrant signaling, a coordinated coupling of EGFR kinase and protein tyrosine phosphatase activity is established through space by vesicular dynamics. The dynamical operation mode of this network enables not only time-varying growth factor sensing but also adaptation of the response depending on cellular context. By connecting spatially coupled enzymatic kinase/phosphatase processes and the corresponding dynamical systems description of the EGFR network, we elaborate on the general principles necessary for processing complex growth factor signals.