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Deep CEST MR Fingerprinting at 7T Reveals Tumor Apoptotic Response to Oncolytic Virotherapy In Vivo

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Herz,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zaiss,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Perlman, O., Ito, H., Herz, K., Shono, N., Nakashima, H., Zaiss, M., et al. (2020). Deep CEST MR Fingerprinting at 7T Reveals Tumor Apoptotic Response to Oncolytic Virotherapy In Vivo. Poster presented at 11th Annual Scientific Symposium on Ultrahigh Field Magnetic Resonance: Clinical Needs, Research Promises and Technical Solutions, Berlin, Germany.


Cite as: http://hdl.handle.net/21.11116/0000-0007-37C4-E
Abstract
Oncolytic virotherapy (OV) is a promising treatment for high mortality cancers.1Non-invasive monitoring of OV is essential for optimizing the clinical outcome and providing an improved understanding of the interactions between the virus and its tumor-host. Chemical exchange saturation transfer (CEST) MRI is a molecular imaging technique that may shed new light on OV, as it is capable of detecting pro-tein concentration and pH changes. However, clinical translation of CEST methods has been hindered by the qualitative nature of the image contrast and the long image acquisition times.