Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity


Lucas,  Kurt
Multiphase Chemistry, Max Planck Institute for Chemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Garzon-Porras, A. M., Bertuzzi, D. L., Lucas, K., da Silva, L. C. E., de Oliveira, M. G., & Ornelas, C. (2020). Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity. ACS applied polymer materials, 2(5), 2027-2034. doi:10.1021/acsapm.0c00203.

Cite as: https://hdl.handle.net/21.11116/0000-0007-4D63-4
Inflammatory processes are related to a wide variety of diseases with high global impact. Nitric oxide (NO) is an excellent candidate for the treatment of such diseases due to its important anti-inflammatory role in living systems, which is related to its concentration in the cellular medium that in turn depends directly on its release rate from NO releasing compounds. In this work, we synthesized a nitrate-terminated dendrimer and evaluated its anti-inflammatory properties. Remarkably, dendrimer bearing 18 NO-releasing groups was nontoxic, and exhibited anti-inflammatory activity (13.7–27.9% of IL-8 inhibition) throughout the tested concentrations (6.50 × 10–2 to 4.17 × 103 nM of dendrimer; (1.17–7.50) × 104 nM of NO-moiety). On the other hand, the NO-releasing monomer was pro-inflammatory at concentrations higher than 62.5 nM. Investigation of the NO-releasing profiles from monomer and dendrimer using real-time NO analyzer NOA confirmed the slow release of NO from the dendrimer. Our results suggest that the NO release from the dendrimer occurs in a controlled fashion, keeping the anti-inflammatory effect of NO even at high concentrations.