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Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man

MPG-Autoren
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Seidel,  Jan
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Bockhop,  Fabian
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182305

Mitkovski,  Miso
Light microscopy facility, Wiss. Servicegruppen, Max Planck Institute of Experimental Medicine, Max Planck Society;

/persons/resource/persons182288

Martin,  Sabine
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Ronnenberg,  Anja
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

Krueger‐Burgi,  Dilja
Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Schneider,  Katharina
Light microscopy facility, Wiss. Servicegruppen, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Röhse,  Heiko
Light microscopy facility, Wiss. Servicegruppen, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Wüstefeld,  Liane
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Bröking,  Kai
Light microscopy facility, Wiss. Servicegruppen, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Ehrenreich,  Hannelore
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Zitation

Seidel, J., Bockhop, F., Mitkovski, M., Martin, S., Ronnenberg, A., Krueger‐Burgi, D., et al. (2020). Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man. FASEB BioAdvances, 2, 18-32. doi:10.1096/fba.2019-00085.


Zitierlink: https://hdl.handle.net/21.11116/0000-0007-496E-D
Zusammenfassung
To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique “sociophobia” acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non-invasive method of stress-monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher Centralization Index (body/tail temperature) in the SocioBox correlated negatively with social recognition memory and, after 4 weeks, with social preference in the Y-maze. Assuming that social stimuli might be associated with characteristic thermo-responses, we exposed healthy men (N = 103) with a comparably high intelligence level to a standardized test session including two cognitive tests with or without social component (face versus pattern recognition). In some analogy to the Centralization Index (within-subject measure) used in mice, the Reference Index (ratio nose/malar cheek temperature) was introduced to determine the autonomic facial response/flushing during social recognition testing. Whereas cognitive performance and salivary cortisol were comparable across human subjects and tests, the Face Recognition Test was associated with a characteristic Reference Index profile. Infrared thermography may have potential for discriminating disturbed social behaviors.