How mRNA localization and protein synthesis sites influence dendritic protein 
distribution and dynamics

Fonkeu, Y.; Kraynyukova, N.; Hafner, A.S.; Kochen, L.; Sartori, F.; Schuman, E. M.; Tchumatchenko, T.

doi:10.1016/j.neuron.2019.06.022

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How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics

MPS-Authors

Fonkeu, Y.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Kraynyukova, N.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Hafner, A.S.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Kochen, L.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Sartori, F.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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Schuman, E. M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

Tchumatchenko, T.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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Citation

Fonkeu, Y., Kraynyukova, N., Hafner, A., Kochen, L., Sartori, F., Schuman, E. M., et al. (2020). How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics. Neuron, 103(6), 1109-1122. doi:10.1016/j.neuron.2019.06.022.

Cite as: https://hdl.handle.net/21.11116/0000-0007-A89E-A

Abstract

In this issue ofNeuron,Fonkeu et al. (2019)present a mathematical model of mRNA and protein synthesis,degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distributionand temporal dynamics of proteins along dendrites. The authors use the model to account forin situimagingdata of CaMKII⍺mRNA and protein in hippocampal neurons.