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Evidence of motor injury due to damaged corticospinal tract following acute hemorrhage in the basal ganglia region

MPG-Autoren
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Wei,  Xuehu
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Li, J., Wei, X., Liu, Y. K., Chen, L. S., Zhu, Z. Q., Hou, S. Y., et al. (2020). Evidence of motor injury due to damaged corticospinal tract following acute hemorrhage in the basal ganglia region. Scientific Reports, 10(1): 16346. doi:10.1038/s41598-020-73305-8.


Zitierlink: https://hdl.handle.net/21.11116/0000-0007-60F0-D
Zusammenfassung
The integrity of the corticospinal tract (CST) is significantly affected following basal ganglia haemorrhage. We aimed to assess the local features of CST and to effectively predict motor function by diffusion characteristics of CST in patients with motor injury following acute haemorrhage in the acute basal ganglia region. We recruited 37 patients with paresis of the lateral limbs caused by acute basal ganglia haemorrhage. Based on the automated fiber quantification method to track CST, assessed the character of each CST segment between the affected and contralateral sides, and correlated these with the Fugl–Meyer (FM) and Barthel Index (BI) scores at 6 months after onset. The fractional anisotropy (FA) values of the injured side of CST showed a significantly lower FA than the contralateral side along the tract profiles (p < 0.05, corrections for multiple comparisons). The FA values of each site at the internal capsule, closed corona radiata were positively correlated with the FM and BI score at 6 months after onset (p < 0.001, respectively). Our findings assessed the character of CST vividly in detail and dementated the primary sites of CST can predict the long-term outcome of motor function. This study may facilitate future clinical and cognitive studies of acute haemorrhage.