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Modulation of premotor cortex response to sequence motor learning during escitalopram intake

MPS-Authors
/persons/resource/persons227471

Molloy,  Eoin
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19872

Mueller,  Karsten
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Beinhölzl,  Nathalie
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Blöchl,  Maria
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Psychology, Münster University, Germany;

Piecha,  Fabian A.
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pampel,  André
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Scharrer,  Ulrike
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Zheleva,  Gergana
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Sehm,  Bernhard
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Nikulin,  Vadim V.
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia;

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Möller,  Harald E.       
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Sacher,  Julia
Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Clinic for Cognitive Neurology, University of Leipzig, Germany;

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Molloy_Mueller_2021.pdf
(Publisher version), 785KB

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Citation

Molloy, E., Mueller, K., Beinhölzl, N., Blöchl, M., Piecha, F. A., Pampel, A., et al. (2021). Modulation of premotor cortex response to sequence motor learning during escitalopram intake. Journal of Cerebral Blood Flow and Metabolism, 41(6), 1449-1462. doi:10.1177/0271678X20965161.


Cite as: https://hdl.handle.net/21.11116/0000-0007-6748-5
Abstract
The contribution of selective serotonin reuptake inhibitors to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we use functional magnetic resonance imaging in a double-blind, randomized controlled study to assess whether 20 mg escitalopram improves sequence-specific motor performance and modulates cortical motor response in 64 healthy female participants. We found decreased left premotor cortex responses during sequence-specific learning performance comparing single dose and steady escitalopram state. Escitalopram plasma levels negatively correlated with the premotor cortex response. We did not find evidence in support of improved motor performance after a week of escitalopram intake. These findings do not support the conclusion that one week escitalopram intake increases motor performance but could reflect early adaptive plasticity with improved neural processing underlying similar task performance when steady peripheral escitalopram levels are reached.