Surface patterning for the control of receptor clustering and molecular forces 
of integrin-mediated adhesions

Pennarola, Federica; Cavalcanti-Adam, Elisabetta Ada

doi:10.1007/978-1-0716-0962-0_11

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Surface patterning for the control of receptor clustering and molecular forces of integrin-mediated adhesions

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Pennarola, Federica
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Cavalcanti-Adam, Elisabetta Ada
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Pennarola, F., & Cavalcanti-Adam, E. A. (2021). Surface patterning for the control of receptor clustering and molecular forces of integrin-mediated adhesions. In M. Vicente-Manzanares (Ed.), The Integrin Interactome (pp. 183-195). New York, NY: Humana Press. doi:10.1007/978-1-0716-0962-0_11.

Cite as: https://hdl.handle.net/21.11116/0000-0007-7257-7

Abstract

Surface nanopatterning allows for the creation of spatially controlled binding sites for extracellular matrix
ligands and the modulation of receptor binding sites. Here we describe the preparation of gold nanopatterned
substrates using diblock micellar nanolithography to immobilize integrin ligands at defined spacing
and combined with molecular tension sensors to measure molecular forces as function of integrin lateral
clustering.