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Cancer-related cognitive impairment in older adults

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Draganski,  Bogdan
Centre Leenaards de la mémoire, Centre hospitalier universitaire vaudois, Lausanne, Switzerland;
Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN), Centre hospitalier universitaire vaudois, Lausanne, Switzerland;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Citation

Baratali, L., Major, K., Rouaud, O., & Draganski, B. (2020). Cancer-related cognitive impairment in older adults. Revue Médicale Suisse, 16(714), 2172-2175.


Cite as: http://hdl.handle.net/21.11116/0000-0007-7302-5
Abstract
Chemotherapy is associated with transient or permanent cognitive dysfunction ranging from subjective complaints to measurable deficits in working memory, attention and language. Given that old age may be related to cognitive decline, the interaction between chemotherapy-induced cognitive impairment and the effects of age is of growing concern in view of our aging population. Chemotherapy-associated cognitive dysfunction may have an additive impact on pre-existing age-related cognitive performance decline, which calls for awareness in its detection, to reduce impact on quality of life and improve management of older patients. We discuss here the « chemobrain », concept, review the existing evidence about pathophysiology, neuroimaging and cognitive phenotype and propose practical tools for routine detection in the outpatient setting.