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Journal Article

Mechanical modes of 'amoeboid' cell migration

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Lämmermann,  Tim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Citation

Lämmermann, T., & Sixt, M. (2009). Mechanical modes of 'amoeboid' cell migration. Current Opinion in Cell Biology, 21, 636-644. doi:10.1016/j.ceb.2009.05.003.


Cite as: http://hdl.handle.net/21.11116/0000-0007-73CF-F
Abstract
The morphological term 'amoeboid' migration subsumes a number of rather distinct biophysical modes of cellular locomotion that range from blebbing motility to entirely actin-polymerization-based gliding. Here, we discuss the diverse principles of force generation and force transduction that lead to the distinct amoeboid phenotypes. We argue that shifting the balance between actin protrusion, actomyosin contraction, and adhesion to the extracellular substrate can explain the different modes of amoeboid movement and that blebbing and gliding are barely extreme variants of one common migration strategy. Depending on the cell type, physiological conditions or experimental manipulation, amoeboid cells can adopt the distinct mechanical modes of amoeboid migration.