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Journal Article

γ-Parvin Is Dispensable for Hematopoiesis, Leukocyte Trafficking, and T-Cell-Dependent Antibody Response


Lämmermann,  Tim
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Chu, H., Thievessen, I., Sixt, M., Lämmermann, T., Waisman, A., Braun, A., et al. (2006). γ-Parvin Is Dispensable for Hematopoiesis, Leukocyte Trafficking, and T-Cell-Dependent Antibody Response. Molecular and Cellular Biology (Washington, DC), 26, 1817-1825. doi:10.1128/MCB.26.5.1817-1825.2006.

Cite as: https://hdl.handle.net/21.11116/0000-0007-74B8-7
Integrins regulate cell behavior through the assembly of multiprotein complexes at the site of cell adhesion. Parvins are components of such a multiprotein complex. They consist of three members (α-, β-, and γ-parvin), form a functional complex with integrin-linked kinase (ILK) and PINCH, and link integrins to the actin cytoskeleton. Whereas α- and β-parvins are widely expressed, γ-parvin has been reported to be expressed in hematopoietic organs. In the present study, we report the expression pattern of the parvins in hematopoietic cells and the phenotypic analysis of γ-parvin-deficient mice. Whereas α-parvin is not expressed in hematopoietic cells, β-parvin is only found in myeloid cells and γ-parvin is present in both cells of the myeloid and lymphoid lineages, where it binds ILK. Surprisingly, loss of γ-parvin expression had no effect on blood cell differentiation, proliferation, and survival and no consequence for the T-cell-dependent antibody response and lymphocyte and dendritic cell migration. These data indicate that despite the high expression of γ-parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis.