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Diffusion and steady state distributions of flexible chemotactic enzymes

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Agudo-Canalejo,  Jaime
Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Golestanian,  Ramin
Department of Living Matter Physics, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Citation

Agudo-Canalejo, J., & Golestanian, R. (2020). Diffusion and steady state distributions of flexible chemotactic enzymes. The European Physical Journal Special Topics, 229, 2791-2806. doi:10.1140/epjst/e2020-900224-3.


Cite as: http://hdl.handle.net/21.11116/0000-0007-750E-7
Abstract
Many experiments in recent years have reported that, when exposed to their corresponding substrate, catalytic enzymes undergo enhanced diffusion as well as chemotaxis (biased motion in the direction of a substrate gradient). Among other possible mechanisms, in a number of recent works we have explored several passive mechanisms for enhanced diffusion and chemotaxis, in the sense that they require only binding and unbinding of the enzyme to the substrate rather than the catalytic reaction itself. These mechanisms rely on conformational changes of the enzyme due to binding, as well as on phoresis due to non-contact interactions between enzyme and substrate. Here, after reviewing and generalizing our previous findings, we extend them in two different ways. In the case of enhanced diffusion, we show that an exact result for the long-time diffusion coefficient of the enzyme can be obtained using generalized Taylor dispersion theory, which results in much simpler and transparent analytical expressions for the diffusion enhancement. In the case of chemotaxis, we show that the competition between phoresis and binding-induced changes in diffusion results in non-trivial steady state distributions for the enzyme, which can either accumulate in or be depleted from regions with a specific substrate concentration.