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Journal Article

Glycoconjugates for glucose transporter-mediated cancer-specific targeting and treatment


Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Fu, J., Yang, J., Seeberger, P. H., & Yin, J. (2020). Glycoconjugates for glucose transporter-mediated cancer-specific targeting and treatment. Carbohydrate Research, 498: 108195. doi:10.1016/j.carres.2020.108195.

Cite as: http://hdl.handle.net/21.11116/0000-0007-7E2B-D
First observed in 1920s, the Warburg effects have inspired scientists to harness the unique glucose metabolism of cancer cells for targeted therapy for a century. Carbohydrate-drug conjugates are explicitly designed for selective uptake by cancer cells overexpressing glucose transporters. We summarize the progress in developing glycoconjugates for cancer-specific targeting and treatment over the past decade (2010–2020) and point to some future directions in this field.