Toward Increased Reliability, Transparency, and Accessibility in Cross-linking 
Mass Spectrometry

Leitner, Alexander; Bonvin, Alexandre M. J. J.; Borchers, Christoph H.; Chalkley, Robert J.; Chamot-Rooke, Julia; Combe, Colin W.; Cox, Jürgen; Dong, Meng-Qiu; Fischer, Lutz; Gotze, Michael; Gozzo, Fabio C.; Heck, Albert J. R.; Hoopmann, Michael R.; Huang, Lan; Ishihama, Yasushi; Jones, Andrew R.; Kalisman, Nir; Kohlbacher, Oliver; Mechtler, Karl; Moritz, Robert L.; Netz, Eugen; Novak, Petr; Petrotchenko, Evgeniy; Sali, Andrej; Scheltema, Richard A.; Schmidt, Carla; Schriemer, David; Sinz, Andrea; Sobott, Frank; Stengel, Florian; Thalassinos, Konstantinos; Urlaub, Henning; Viner, Rosa; Vizcaino, Juan A.; Wilkins, Marc R.; Rappsilber, Juri

doi:10.1016/j.str.2020.09.011

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Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry

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Cox, Jürgen
Cox, Jürgen / Computational Systems Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Leitner, A., Bonvin, A. M. J. J., Borchers, C. H., Chalkley, R. J., Chamot-Rooke, J., Combe, C. W., et al. (2020). Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry. Structure, 28(11), 1259-1268. doi:10.1016/j.str.2020.09.011.

Cite as: https://hdl.handle.net/21.11116/0000-0007-8D25-1

Abstract

Cross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.