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Journal Article

Expamers: a new technology to control T cell activation

MPS-Authors
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Turk,  Martin
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Plitzko,  Jürgen
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Fulltext (public)

s41598-020-74595-8.pdf
(Publisher version), 3MB

Supplementary Material (public)

41598_2020_74595_MOESM1_ESM.pdf
(Supplementary material), 2MB

41598_2020_74595_MOESM2_ESM.pdf
(Supplementary material), 632KB

Citation

Poltorak, M. P., Graef, P., Tschulik, C., Wagner, M., Cletiu, V., Dreher, S., et al. (2020). Expamers: a new technology to control T cell activation. Scientific Reports, 10(1): 17832. doi:10.1038/s41598-020-74595-8.


Cite as: http://hdl.handle.net/21.11116/0000-0007-DF9E-D
Abstract
T cell activation is a cornerstone in manufacturing of T cell-based therapies, and precise control over T cell activation is important in the development of the next generation T-cell based therapeutics. This need cannot be fulfilled by currently available methods for T cell stimulation, in particular not in a time dependent manner. Here, we describe a modular activation reagent called Expamers, which addresses these limitations. Expamers are versatile stimuli that are intended for research and clinical use. They are readily soluble and can be rapidly bound and removed from the cell surface, allowing nearly instantaneous initiation and termination of activation signal, respectively. Hence, Expamers enable precise regulation of T cell stimulation duration and provide promise of control over T cell profiles in future products. Expamers can be easily adopted to different T cell production formats and have the potential to increase efficacy of T cell immunotherapeutics.