Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated 
Quality Control

Sitron, Cole S.; Brandman, Onn

doi:10.1146/annurev-biochem-013118-110729

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Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control

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Sitron, Cole S.
Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society;

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Sitron, C. S., & Brandman, O. (2020). Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control. Annual Review of Biochemistry, 89(1), 417-442. doi:10.1146/annurev-biochem-013118-110729.

Cite as: https://hdl.handle.net/21.11116/0000-0007-8CCC-6

Abstract

Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.