A model for spatio-temporal dynamics in a regulatory network for cell polarity 
(vol 258, pg 189, 2014)

Rashkov, P.; Schmitt, B.; Keilberg, D.; Beck, Kristof; Sogaard-Andersen, L.; Dahlke, S.

doi:10.1016/j.mbs.2014.10.005

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A model for spatio-temporal dynamics in a regulatory network for cell polarity (vol 258, pg 189, 2014)

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Keilberg, D.
Bacterial Adaption and Differentiation, Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Sogaard-Andersen, L.
Bacterial Adaption and Differentiation, Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Zitation

Rashkov, P., Schmitt, B., Keilberg, D., Beck, K., Sogaard-Andersen, L., & Dahlke, S. (2015). A model for spatio-temporal dynamics in a regulatory network for cell polarity (vol 258, pg 189, 2014). Mathematical Biosciences, 264, 145-145. doi:10.1016/j.mbs.2014.10.005.

Zitierlink: https://hdl.handle.net/21.11116/0000-0007-BCE9-F

Zusammenfassung

Cell polarity in Myxococcus xanthus is crucial for the directed motility of individual cells. The polarity system is characterised by a dynamic spatio-temporal localisation of the regulatory proteins MglA and MglB at opposite cell poles. In response to signalling by the Frz chemosensory system, MglA and MglB are released from the poles and then rebind at the opposite poles. Thus, over time MglA and MglB oscillate irregularly between the poles in synchrony but out of phase. A minimal macroscopic model of the Mgl/Frz regulatory system based on a reaction-diffusion PDE system is presented. Mathematical analysis of the steady states derives conditions on the reaction terms for formation of dynamic localisation patterns of the regulatory proteins under different biologically-relevant regimes, i.e. with and without Frz signalling. Numerical simulations of the model system produce either a stationary pattern in time (fixed polarity), periodic solutions in time (oscillating polarity), or excitable behaviour (irregular switching of polarity).