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Two Small GTPases Act in Concert with the Bactofilin Cytoskeleton to Regulate Dynamic Bacterial Cell Polarity

MPG-Autoren
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Bulyha,  I.
Bacterial Adaption and Differentiation, Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Lindow,  S.
Bacterial Adaption and Differentiation, Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Lin,  L.
Max Planck Fellow Bacterial Cell Biology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Wuichet,  K.
Bacterial Adaption and Differentiation, Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Kahnt,  J.
Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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van der Does,  C.
Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Thanbichler,  M.
Max Planck Fellow Bacterial Cell Biology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Sogaard-Andersen,  L.
Bacterial Adaption and Differentiation, Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Zitation

Bulyha, I., Lindow, S., Lin, L., Bolte, K., Wuichet, K., Kahnt, J., et al. (2013). Two Small GTPases Act in Concert with the Bactofilin Cytoskeleton to Regulate Dynamic Bacterial Cell Polarity. Developmental Cell, 25(2), 119-131. doi:10.1016/j.devcel.2013.02.017.


Zitierlink: https://hdl.handle.net/21.11116/0000-0007-BF85-C
Zusammenfassung
Cell polarity is essential for many bacterial activities, but the mechanisms responsible for its establishment are poorly understood. In Myxococcus xanthus, the type IV pili (T4P) motor ATPases PilB and PilT localize to opposite cell poles and switch poles during cellular reversals. We demonstrate that polar localization of PilB and PilT depends on the small GTPase SofG and BacP, a bactofilin cytoskeletal protein. Polymeric BacP localizes in both subpolar regions. SofG interacts directly with polymeric BacP and associates with one of these patches, forming a cluster that shuttles to the pole to establish localization of PilB and PilT at the same pole. Next, the small GTPase MglA sorts PilB and PilT to opposite poles to establish their correct polarity. During reversals, the Frz chemosensory system induces the inversion of PilB and PilT polarity. Thus, three hierarchically organized systems function in a cascade to regulate dynamic bacterial cell polarity.