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Meeting Abstract

Noradrenergic locus coeruleus ensembles fire at distinct times to evoke different cortical states in rat prefrontal cortex

MPS-Authors
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Zouridis,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons192680

Totah,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://areadne.org/2020/pezaris-hatsopoulos-2020-areadne.pdf
(Abstract)

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Citation

Noei, S., Zouridis, I., Logothetis, N., Panzeri, S., & Totah, N. (2020). Noradrenergic locus coeruleus ensembles fire at distinct times to evoke different cortical states in rat prefrontal cortex. In J. Pezaris, & N. Hatsopoulos (Eds.), AREADNE 2020: Research in Encoding and Decoding of Neural Ensembles (pp. 94). Cambridge, MA, USA: The AREADNE Foundation.


Cite as: https://hdl.handle.net/21.11116/0000-0007-987F-0
Abstract
The Locus Coeruleus (LC), a noradrenergic brain stem nucleus projecting throughout the forebrain,
is thought to act as an undifferentiated state controller across all forebrain targets because
LC neurons spike synchronously [1, 2]. However, recent work demonstrated ensembles
in the LC and therefore made targeted neuromodulation a possibility [3]. This recent study
used graph theory to reveal a static snapshot of LC ensembles. In order to now demonstrate
that LC ensembles cause targeted neuromodulation, it is necessary to resolve LC ensemble
dynamics over time in relation to ongoing cortical states.