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The cGMP-gated channel of rod outer segments is not localized in bipolar cells of the mammalian retina

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Wässle,  Heinz
Neuroanatomy Department, Max Planck Institute for Brain Research, Max Planck Society;

Grünert,  Ulrike
Neuroanatomy Department, Max Planck Institute for Brain Research, Max Planck Society;

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Cook,  Neil J.
Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Wässle, H., Grünert, U., Cook, N. J., & Molday, R. S. (1992). The cGMP-gated channel of rod outer segments is not localized in bipolar cells of the mammalian retina. Neuroscience Letters, 134(2), 199-202. doi:10.1016/0304-3940(92)90516-A.


Cite as: http://hdl.handle.net/21.11116/0000-0007-A08A-8
Abstract
It has recently been suggested (Nature, 346 (1990) 269–271) that ON-bipolar cells express the same biochemical cascade and guanosine 3′,5′-cyclic monophosphate (cGMP)-gated cation channel as rod outer segments. An antibody directed against the cGMP-gated channel of bovine rod outer segments was applied to cryostat sections of rat and cat retinae. No immunocytochemical labelling was found in bipolar cells. Therefore, if those cells express a cGMP-gated channel, it must be immunologically different to the 63 kDa protein constituting the cGMP-gated channel of the outer segment.