Primary structure and functional expression from complementary DNA of the rod 
photoreceptor cyclic GMP-gated channel

Kaupp, Ulrich Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stuehmer, Walther; Cook, Neil J.; Kangawa, Kenji; Matsuo, Hisayuki; Hirose, Tadaaki; Miyata, Takashi; Numa, Shosaku

doi:10.1038/342762a0

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Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel

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Stuehmer, Walther
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Cook, Neil J.
Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society;
Abteilung Biophysik, Universität Osnabrück, D-4500 Osnabrück, Germany;

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Citation

Kaupp, U. B., Niidome, T., Tanabe, T., Terada, S., Bönigk, W., Stuehmer, W., et al. (1989). Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature, 342(6251), 762-766. doi:10.1038/342762a0.

Cite as: https://hdl.handle.net/21.11116/0000-0007-A08C-6

Abstract

The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photo-receptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, followed by a region that is similar to the cyclic GMP-binding domains of cyclic GMP-dependent protein kinase. Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes