Production of G protein-coupled receptors in yeast

Reiländer, Helmut; Weiß, Markus

doi:10.1016/S0958-1669(98)80038-4

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Production of G protein-coupled receptors in yeast

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Reiländer, Helmut
Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Max Planck Society;

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Reiländer, H., & Weiß, M. (1998). Production of G protein-coupled receptors in yeast. Current Opinion in Biotechnology, 9(5), 510-517. doi:10.1016/S0958-1669(98)80038-4.

Cite as: http://hdl.handle.net/21.11116/0000-0007-A286-A

Abstract

Yeasts combine the advantages of fast and easy handling with the potential to perform eukaryotic post-translational modifications and are for this reason interesting hosts for heterologous production of G-protein-coupled receptors. The possibility to connect foreign receptors to a yeast internal MAP kinase pathway was used to establish yeast-based systems for high-throughput screening of compound libraries. In addition, yeasts have the potential for high level production of G-protein-coupled receptors. In this field, non-Saccharomyces yeasts seems to be interesting alternatives to S. cerevisiae, as well as to systems based on higher eukaryotic cells.