A second E2 for nedd8ylation expands substrate selection

Pichler, Andrea

doi:org/10.1016/j.str.2009.02.003

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A second E2 for nedd8ylation expands substrate selection

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Pichler, Andrea
Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.cell.com/structure/references/S0969-2126(09)00080
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Citation

Pichler, A. (2009). A second E2 for nedd8ylation expands substrate selection. Structure, 17, 321-322. doi:org/10.1016/j.str.2009.02.003.

Cite as: https://hdl.handle.net/21.11116/0000-0007-A75C-6

Abstract

The ubiquitin-like modifier NEDD8 promotes substrate ubiquitination via its covalent linkage to ubiquitin cullin-RING ligases. This depends on a NEDD8-specific sequential enzymatic cascade of E1, E2, and E3 enzymes. The identification of a second E2 enzyme for nedd8ylation recently reported in Molecular Cell (Huang et al., 2009) reveals novel insights into the molecular mechanism of target cullin selection.