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Journal Article

Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey

MPS-Authors
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Förster,  Dominique
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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Helmbrecht,  Thomas O.
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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Mearns,  Duncan S.
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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Jordan,  Linda
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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Mokayes,  Nouwar
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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Baier,  Herwig
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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Fulltext (public)

elife-58596-v1.pdf
(Publisher version), 9MB

Supplementary Material (public)

elife-58596-figures-v1.pdf
(Supplementary material), 13MB

Citation

Förster, D., Helmbrecht, T. O., Mearns, D. S., Jordan, L., Mokayes, N., & Baier, H. (2020). Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey. eLife, 9: e58596. doi:10.7554/eLife.58596.


Cite as: http://hdl.handle.net/21.11116/0000-0007-AB94-1
Abstract
Retinal axon projections form a map of the visual environment in the tectum. A zebrafish larva typically detects a prey object in its peripheral visual field. As it turns and swims towards the prey, the stimulus enters the central, binocular area, and seemingly expands in size. By volumetric calcium imaging, we show that posterior tectal neurons, which serve to detect prey at a distance, tend to respond to small objects and intrinsically compute their direction of movement. Neurons in anterior tectum, where the prey image is represented shortly before the capture strike, are tuned to larger object sizes and are frequently not direction-selective, indicating that mainly interocular comparisons serve to compute an object's movement at close range. The tectal feature map originates from a linear combination of diverse, functionally specialized, lamina-specific, and topographically ordered retinal ganglion cell synaptic inputs. We conclude that local cell-type composition and connectivity across the tectum are adapted to the processing of locationdependent, behaviorally relevant object features.