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Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

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Guidi,  Mara
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Moon,  Soo-Yeon
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Anghileri,  Lucia
Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Cambié,  Dario
Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Gilmore,  Kerry
Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Guidi, M., Moon, S.-Y., Anghileri, L., Cambié, D., Seeberger, P. H., & Gilmore, K. (2021). Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines. Reaction Chemistry & Engineering. doi:10.1039/D0RE00445F.


Cite as: http://hdl.handle.net/21.11116/0000-0007-AC26-D
Abstract
Current drug production in batch cannot adapt rapidly to market demands,} evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand production of active pharmaceutical ingredients (APIs). Here{,} we reveal a new concept to develop and produce APIs{,} where an automated synthesizer that works with discrete volumes of solutions is employed at the discovery stage to identify the optimal synthetic route and conditions before a commercially available continuous flow system is used for scale-up. This concept is illustrated by the synthesis of nifedipine and paracetamol{,} in short supply in Germany during the COVID-19 pandemic{, and the local anesthetic lidocaine.