English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

MPS-Authors
/persons/resource/persons226739

Dikic,  Ivan
Max Planck Fellow Group ER remodelling Group, Prof. Ivan Đikić, Max Planck Institute of Biophysics, Max Planck Society;
Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt, Germany;
Institute of Biochemistry 2, Faculty of Medicine, Goethe Uiversty Frankfurt, Frankfurt, Germany;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Wells, C. I., Al-Ali, H., Andrews, D. M., Asquith, C. R. M., Axtman, A. D., Dikic, I., et al. (2021). The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International Journal of Molecular Sciences, 22(2): 566. doi:10.3390/ijms22020566.


Cite as: http://hdl.handle.net/21.11116/0000-0007-AD19-B
Abstract
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.