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Journal Article

Species differences between rat and rabbit renal Na+/H+ exchangers

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Friedrich,  Thomas
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Sablotni,  Jutta
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Burckhardt,  Gerhard
Department of Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Friedrich, T., Sablotni, J., & Burckhardt, G. (1987). Species differences between rat and rabbit renal Na+/H+ exchangers. Biochemical and Biophysical Research Communications, 144(2), 869-875. doi:10.1016/s0006-291x(87)80045-1.


Cite as: https://hdl.handle.net/21.11116/0000-0007-D2D3-D
Abstract
Amiloride, 5-ethylisopropylamiloride (EIPA), and 5-ethylisopropyl-6-bromo-amiloride (Br-EIPA) inhibit rabbit and rat renal Na+/H+ exchangers with comparable potency. Irreversible inhibitions by Br-EIPA after irradiation of rat and rabbit renal brush-border vesicles are also similar. In contrast, irreversible inhibition by N,N'-dicyclohexylcarbodiimide (DCCD) of the rabbit renal antiporter requires higher DCCD concentrations as compared to the rat. Rabbit renal brush-border membranes show highest [14C]DCCD incorporation at MW 80,000, 51,000 and 36,000 and lack the amiloride-protectable MW 65,000 protein previously identified as Na+/H+ exchanger in rat kidney cortex. The data indicate species differences with respect to renal Na+/H+ exchangers.