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Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts

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Johnsson,  Kai
Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Fujioka, H., Uno, S.-n., Kamiya, M., Kojima, R., Johnsson, K., & Urano, Y. (2020). Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts. Chemical Communications, 56(42), 5617-5620. doi:10.1039/d0cc00559b.


Cite as: http://hdl.handle.net/21.11116/0000-0007-B0FF-3
Abstract
We show that the equilibrium of intramolecular spirocyclization of coumarin-hemicyanine hybrid fluorophores can be finely tuned by means of chemical modifications. We used this scaffold to develop activatable fluorescent probes with large Stokes shifts for γ-glutamyltranspeptidase and esterase.