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Journal Article

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility

MPS-Authors
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Gong,  An
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Alvarez,  Luis
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;
Max Planck Research Group Neural Information Flow, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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https://science.sciencemag.org/content/371/6525/eabd4914
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Citation

Gadadhar, S., Alvarez Viar, G., Hansen, J. N., Gong, A., Kostarev, A., Ialy-Radio, C., et al. (2021). Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Science, 371(6525): eabd4914. doi:10.1126/science.abd4914.


Cite as: https://hdl.handle.net/21.11116/0000-0007-B23D-C
Abstract
Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. Tubulin glycylation modifies microtubules specifically in cilia and flagella, but its functional and mechanistic roles remain unclear. In this study, we generated a mouse model entirely lacking tubulin glycylation. Male mice were subfertile owing to aberrant beat patterns of their sperm flagella, which impeded the straight swimming of sperm cells. Using cryo–electron tomography, we showed that lack of glycylation caused abnormal conformations of the dynein arms within sperm axonemes, providing the structural basis for the observed dysfunction. Our findings reveal the importance of microtubule glycylation for controlled flagellar beating, directional sperm swimming, and male fertility.