Amplification and direct sequencing of a cDNA encoding human cytosolic 
3-hydroxy-3- methylglutaryl-coenzyme A synthase

Russ, Andreas P.; Ruzicka, Viktor; Maerz, Winfried; Appelhans, Heribert; Groß, Werner

doi:10.1016/0167-4781(92)90172-v

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Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3- methylglutaryl-coenzyme A synthase

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Appelhans, Heribert
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Russ, A. P., Ruzicka, V., Maerz, W., Appelhans, H., & Groß, W. (1992). Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3- methylglutaryl-coenzyme A synthase. Biochimica et Biophysica Acta-Gene Structure and Expression, 1132(3), 329-331. doi:10.1016/0167-4781(92)90172-v.

Cite as: https://hdl.handle.net/21.11116/0000-0007-E8C9-1

Abstract

Cytosolic 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) synthase (E.C. 4.1.3.5) is a highly regulated enzyme involved in isoprenoid biosynthesis and therefore a potential target for cholesterol-lowering drugs. Up to now, primary structure data have only been available for chicken, rat and hamster HMG-CoA synthase. Using in vitro amplification and direct sequencing, we have determined the nucleotide sequence of the coding region of the human cytosolic 3-hydroxy-3-methylglutaryl CoA synthase cDNA.