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Robustness and timing of cellular differentiation through population-based symmetry breaking

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Stanoev,  Angel
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Schröter,  Christian
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Koseska,  Aneta
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;
Lise Meitner Group Cellular Computations and Learning, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Citation

Stanoev, A., Schröter, C., & Koseska, A. (2019). Robustness and timing of cellular differentiation through population-based symmetry breaking. Unpublished Manuscript.


Cite as: https://hdl.handle.net/21.11116/0000-0007-CB54-6
Abstract
During mammalian development, cell types expressing mutually exclusive genetic markers are differentiated from a multilineage primed state. These observations have invoked single-cell multistability view as the dynamical basis of differentiation. However, the robust regulative nature of mammalian development is not captured therein. Considering the well-established role of cell-cell communication in this process, we propose a fundamentally different dynamical treatment in which cellular identities emerge and are maintained on population level, as a novel unique solution of the coupled system. Subcritical system’s organization here enables symmetry-breaking to be triggered by cell number increase in a timed, self-organized manner. Robust cell type proportions are thereby an inherent feature of the resulting inhomogeneous solution. This framework is generic, as exemplified for early embryogenesis and neurogenesis cases. Distinct from mechanisms that rely on pre-existing asymmetries, we thus demonstrate that robustness and accuracy necessarily emerge from the cooperative behaviour of growing cell populations during development.