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Journal Article

NK1.1+ innate lymphoid cells in salivary glands inhibit establishment of tissue-resident memory CD8+ T cells in mice

MPS-Authors

Pircher,  Hanspeter
Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

External Resource

https://onlinelibrary.wiley.com/doi/10.1002/eji.202048741
(Publisher version)

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Citation

Woyciechowski, S., Weißert, K., Ammann, S., Aichele, P., & Pircher, H. (2020). NK1.1+ innate lymphoid cells in salivary glands inhibit establishment of tissue-resident memory CD8+ T cells in mice. Eur j Immunol, 50, 1952-1958. doi:10.1002/eji.202048741.


Cite as: https://hdl.handle.net/21.11116/0000-0007-D169-7
Abstract
NK1.1+ cells found in salivary glands (SG) represent a unique cell population of innate lymphoid cells (ILC) with characteristics of both conventional NK cells and ILC1. Here, we demonstrate that these NK1.1+ cells limit the accumulation and differentiation of virus‐specific tissue‐resident memory CD8+ T cells (TRM cells) in SG of mice infected with lymphocytic choriomeningitis virus (LCMV). The negative regulation of LCMV‐specific CD8+ TRM cells by NK1.1+ cells in SG is independent of NKG2D, NKp46, TRAIL, and perforin. Moreover, analysis of NKp46iCre+Eomesfl/fl mice revealed that Eomes‐dependent conventional NK cells are dispensable for negative regulation. Since the SG are prone to autoimmune reactions, regulation of TRM cells by tissue‐resident ILC may be particularly important to prevent immunopathology in this organ.