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Journal Article

Asymmetric inhibition by phlorizin of sulfate movements across the red blood cell membrane

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Lepke,  Sigrid
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Passow,  Hermann
Department of Cell Physiology, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Lepke, S., & Passow, H. (1973). Asymmetric inhibition by phlorizin of sulfate movements across the red blood cell membrane. Biochimica et Biophysica Acta-Biomembranes, 298(2), 529-533. doi:10.1016/0005-2736(73)90379-9.


Cite as: https://hdl.handle.net/21.11116/0000-0008-711A-C
Abstract
Measuring SO42− exchange across the red cell membrane at Donnan equilibrium, it was found that extracellular phlorizin inhibited SO42− movements while intracellular phlorizin did not. This asymmetric action of phlorizin on anion permeability is in contrast to the effect on the permeability to d-xylose. In accordance with previous findings of Beneš, I., Kolinská, J. and Kotyk, A. (1972) J. Membrane Biol. 8, 303, the penetration of the sugar was inhibited by phlorizin from either surface. It is concluded that phlorizin inhibition of anion transfer across the red cell membrane is due to interactions with binding sites which are located at the outer surface of the membrane and which do not diffuse all the way through the membrane like a sugar carrier or a lipid-soluble ionophore.