Triacylglycerol synthesis enhances macrophage inflammatory function

Castoldi, Angela; Monteiro, Lauar B.; van Bakker, Nikki Teijlingen; Sanin, David E.; Rana, Nisha; Corrado, Mauro; Cameron, Alanna M.; Hässler, Fabian; Matsushita, Mai; Caputa, George; Geltink, Ramon I. Klein; Büscher, Jörg; Edwards-Hicks, Joy; Pearce, Erika L.; Pearce, Edward J.

doi:doi.org/10.1038/s41467-020-17881-3

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Triacylglycerol synthesis enhances macrophage inflammatory function

MPS-Authors

Castoldi, Angela
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Monteiro, Lauar B.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

van Bakker, Nikki Teijlingen
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Sanin, David E.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Rana, Nisha
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Corrado, Mauro
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Cameron, Alanna M.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Hässler, Fabian
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Matsushita, Mai
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Caputa, George
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Geltink, Ramon I. Klein
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Büscher, Jörg
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Edwards-Hicks, Joy
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Pearce, Erika L.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

/persons/resource/persons201435

Pearce, Edward J.
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.nature.com/articles/s41467-020-17881-3
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Citation

Castoldi, A., Monteiro, L. B., van Bakker, N. T., Sanin, D. E., Rana, N., Corrado, M., et al. (2020). Triacylglycerol synthesis enhances macrophage inflammatory function. Nature Communications, 11, 1-11. doi:doi.org/10.1038/s41467-020-17881-3.

Cite as: https://hdl.handle.net/21.11116/0000-0007-E1E1-C

Abstract

Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in macrophages. Here we explore the basis and significance of this process. Our findings indicate that LD development is the result of metabolic commitment to TG synthesis on a background of decreased fatty acid oxidation. TG synthesis is essential for optimal inflammatory macrophage activation as its inhibition, which prevents LD development, has marked effects on the production of inflammatory mediators, including IL-1β, IL-6 and PGE2, and on phagocytic capacity. The failure of inflammatory macrophages to make PGE2 when TG-synthesis is inhibited is critical for this phenotype, as addition of exogenous PGE2 is able to reverse the anti-inflammatory effects of TG synthesis inhibition. These findings place LDs in a position of central importance in inflammatory macrophage activation.