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Electrogenic Properties of the Endogenous and of Modified Torpedo Na+/K+-Pumps in Xenopus Oocytes: The Access Channel for External Cations

MPS-Authors
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Schwarz,  Wolfgang
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Vasilets,  Larisa A.
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Omay,  Halit
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Efthymiadis,  A.
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Rettinger,  Jürgen
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Elsner,  S.
Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society;

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Citation

Schwarz, W., Vasilets, L. A., Omay, H., Efthymiadis, A., Rettinger, J., & Elsner, S. (1994). Electrogenic Properties of the Endogenous and of Modified Torpedo Na+/K+-Pumps in Xenopus Oocytes: The Access Channel for External Cations. In E. Bamberg (Ed.), The Sodium Pump (pp. 482-494). Darmstadt, Germany: Steinkopff Verlag GmbH & Co. KG, Darmstadt 1994.


Cite as: http://hdl.handle.net/21.11116/0000-0007-E785-E
Abstract
During the last years we have examined in voltage-clamp experiments the influence of extracellular Na+ and K+ on the current generated by the Na+/K+-pump. As a model system we used the Xenopus oocytes, and we analysed in these cells the endogenous Xenopus pump as well as expressed wild-type and mutated pumps of Torpedo electroplax by means of two-microelectrode and giant-patch voltage clamp. The results allowed us to draw conclusion about possible structure-function relationships of the Na+/K+-ATPase.