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Journal Article

Photo-tethered molecular beacons for superior light-induction

MPS-Authors

Klimek,  R.
Max Planck Society;

Wang,  M.
Max Planck Society;

McKenney,  V. R.
Max Planck Society;

Schuman,  E. M.
Max Planck Society;

Heckel,  A.
Max Planck Society;

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Citation

Klimek, R., Wang, M., McKenney, V. R., Schuman, E. M., & Heckel, A. (2020). Photo-tethered molecular beacons for superior light-induction. Chem Commun (Camb). doi:10.1039/d0cc06704k.


Cite as: http://hdl.handle.net/21.11116/0000-0007-EEE5-B
Abstract
We developed a superior class of light-activatable molecular beacons with photo-tethered loop regions. Two simple modifications and probe cyclisation prevent the molecular beacon from hybridising with the target RNA before light-activation. Full activity of the molecular beacon is elicited upon illumination with 365 nm light.