Photo-tethered molecular beacons for superior light-induction

Klimek, R.; Wang, M.; McKenney, V. R.; Schuman, E. M.; Heckel, A.

doi:10.1039/d0cc06704k

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Journal Article

Photo-tethered molecular beacons for superior light-induction

MPS-Authors

Klimek, R.
Max Planck Society;

Wang, M.
Max Planck Society;

McKenney, V. R.
Max Planck Society;

Schuman, E. M.
Max Planck Society;

Heckel, A.
Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/33346255
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Citation

Klimek, R., Wang, M., McKenney, V. R., Schuman, E. M., & Heckel, A. (2020). Photo-tethered molecular beacons for superior light-induction. Chem Commun (Camb). doi:10.1039/d0cc06704k.

Cite as: https://hdl.handle.net/21.11116/0000-0007-EEE5-B

Abstract

We developed a superior class of light-activatable molecular beacons with photo-tethered loop regions. Two simple modifications and probe cyclisation prevent the molecular beacon from hybridising with the target RNA before light-activation. Full activity of the molecular beacon is elicited upon illumination with 365 nm light.