Preview. Angelman syndrome: finding the lost arc

Tai, H. C.; Schuman, Erin M.

doi:10.1016/j.cell.2010.02.019

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Preview. Angelman syndrome: finding the lost arc

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Schuman, Erin M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/20211128
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Citation

Tai, H. C., & Schuman, E. M. (2010). Preview. Angelman syndrome: finding the lost arc. Cell, 140(5), 608-610. doi:10.1016/j.cell.2010.02.019.

Cite as: https://hdl.handle.net/21.11116/0000-0007-EF28-0

Abstract

Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome.