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Journal Article

A role for BDNF in the late-phase of hippocampal long-term potentiation


Schuman,  Erin M.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

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Korte, M., Kang, H., Bonhoeffer, T., & Schuman, E. M. (1998). A role for BDNF in the late-phase of hippocampal long-term potentiation. Neuropharmacology, 37(4-5), 553-9. doi:10.1016/s0028-3908(98)00035-5.

Cite as: http://hdl.handle.net/21.11116/0000-0007-EF9E-B
The neurotrophin family of growth factors has received enormous attention recently for its role in modulating synaptic strength in the developing and adult nervous system. Several recent studies have indicated a role for brain-derived neurotrophic factor (BDNF) in long-term potentiation (LTP), a form of long-lasting plasticity observed at synapses in the hippocampus and other brain areas. The late-phase (L-LTP; e.g. > 2 h) of LTP has been shown to require the synthesis of new proteins. We have examined whether BDNF or other TrkB ligands participate in L-LTP in two ways: by examining transgenic mice which lack BDNF or by acutely blocking TrkB function using function-blocking antibodies. Slices from BDNF knock-out animals or slices treated with TrkB antibodies failed to exhibit L-LTP, indicating that TrkB ligands participate in extending synaptic enhancement from a short-lasting to a long-lasting form.