Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels 
from Arabidopsis thaliana

Köhler, C.; Neuhaus, Gunther

doi:10.1016/s0014-5793(00)01383-1

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Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana

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Citation

Köhler, C., & Neuhaus, G. (2000). Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana. FEBS Letters, 471(2-3), 133-136. doi:10.1016/s0014-5793(00)01383-1.

Cite as: https://hdl.handle.net/21.11116/0000-0007-EC0C-3

Abstract

The recently identified cyclic nucleotide-gated ion channels (AtCNGCs) from Arabidopsis thaliana have the ability to bind calmodulin. Using two different methods, we mapped the binding site of AtCNGC1 to the last predicted α helix of the cyclic nucleotide binding domain. This is in contrast to CNGCs from animals, where the calmodulin binding site is located in the N-terminus, implying that different mechanisms for CNGC modulation have evolved in animals and plants. Furthermore, we demonstrate that AtCNGC1 and AtCNGC2 have different calmodulin binding affinities and we provide evidence for target specificities among calmodulin isoforms.