High-resolution three-dimensional extracellular recording of neuronal activity 
with microfabricated electrode arrays

Du, J.; Riedel-Kruse, I. H.; Nawroth, J. C.; Roukes, M. L.; Laurent, Gilles; Masmanidis, S. C.

doi:10.1152/jn.90992.2008

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays

MPS-Authors

/persons/resource/persons208073

Laurent, Gilles
Neural systems Department, Max Planck Institute for Brain Research, Max Planck Society;

External Resource

https://www.ncbi.nlm.nih.gov/pubmed/19091921
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Du, J., Riedel-Kruse, I. H., Nawroth, J. C., Roukes, M. L., Laurent, G., & Masmanidis, S. C. (2008). High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays. J Neurophysiol, 101(3), 1671-8. doi:10.1152/jn.90992.2008.

Cite as: https://hdl.handle.net/21.11116/0000-0008-07A8-3

Abstract

Microelectrode array recordings of neuronal activity present significant opportunities for studying the brain with single-cell and spike-time precision. However, challenges in device manufacturing constrain dense multisite recordings to two spatial dimensions, whereas access to the three-dimensional (3D) structure of many brain regions appears to remain a challenge. To overcome this limitation, we present two novel recording modalities of silicon-based devices aimed at establishing 3D functionality. First, we fabricated a dual-side electrode array by patterning recording sites on both the front and back of an implantable microstructure. We found that the majority of single-unit spikes could not be simultaneously detected from both sides, suggesting that in addition to providing higher spatial resolution measurements than that of single-side devices, dual-side arrays also lead to increased recording yield. Second, we obtained recordings along three principal directions with a multilayer array and demonstrated 3D spike source localization within the enclosed measurement space. The large-scale integration of such dual-side and multilayer arrays is expected to provide massively parallel recording capabilities in the brain.