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Journal Article

Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration

MPS-Authors
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Preisig,  Basil
Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;

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Sjerps,  Matthias J.
Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;

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Kösem,  Anne
Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;
Université Claude Bernard Lyon;

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Hagoort,  Peter
Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society;
Donders Institute for Brain, Cognition and Behaviour, External Organizations;

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Supplementary Material (public)

pnas.2015488118.sapp.pdf
(Supplementary material), 756KB

Citation

Preisig, B., Riecke, L., Sjerps, M. J., Kösem, A., Kop, B. R., Bramson, B., et al. (2021). Selective modulation of interhemispheric connectivity by transcranial alternating current stimulation influences binaural integration. Proceedings of the National Academy of Sciences, 118(7): e2015488118. doi:10.1073/pnas.2015488118.


Cite as: http://hdl.handle.net/21.11116/0000-0007-F02D-8
Abstract
Brain connectivity plays a major role in the encoding, transfer, and integration of sensory information. Interregional synchronization of neural oscillations in the γ-frequency band has been suggested as a key mechanism underlying perceptual integration. In a recent study, we found evidence for this hypothesis showing that the modulation of interhemispheric oscillatory synchrony by means of bihemispheric high-density transcranial alternating current stimulation (HD-TACS) affects binaural integration of dichotic acoustic features. Here, we aimed to establish a direct link between oscillatory synchrony, effective brain connectivity, and binaural integration. We experimentally manipulated oscillatory synchrony (using bihemispheric γ-TACS with different interhemispheric phase lags) and assessed the effect on effective brain connectivity and binaural integration (as measured with functional MRI and a dichotic listening task, respectively). We found that TACS reduced intrahemispheric connectivity within the auditory cortices and antiphase (interhemispheric phase lag 180°) TACS modulated connectivity between the two auditory cortices. Importantly, the changes in intra- and interhemispheric connectivity induced by TACS were correlated with changes in perceptual integration. Our results indicate that γ-band synchronization between the two auditory cortices plays a functional role in binaural integration, supporting the proposed role of interregional oscillatory synchrony in perceptual integration.