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Supramammillary Nucleus Modulates Spike-Time Coordination in the Prefrontal-Thalamo-Hippocampal Circuit during Navigation

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Ito,  Hiroshi
Memory and Navigation Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

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Citation

Ito, H., Moser, E. I., & Moser, M. B. (2018). Supramammillary Nucleus Modulates Spike-Time Coordination in the Prefrontal-Thalamo-Hippocampal Circuit during Navigation. Neuron, 99(3), 576-587 e5. doi:10.1016/j.neuron.2018.07.021.


Cite as: http://hdl.handle.net/21.11116/0000-0007-F388-D
Abstract
During navigation, hippocampal spatial maps are thought to interact with action-planning systems in other regions of cortex. We here report a key role for spike-time coordination in functional coupling of the medial prefrontal cortex (mPFC) to the hippocampus through the thalamic nucleus reuniens (NR). When rats perform a T-maze alternation task, spikes of neurons in mPFC and NR exhibit enhanced coordination to the CA1 theta rhythm before the choice point on the maze. A similar coordination to CA1 theta rhythm was observed in neurons of the supramammillary nucleus (SUM). Optogenetic silencing of SUM neurons reduced the temporal coordination in the mPFC-NR-CA1 circuit. Following SUM inactivation, trajectory representations were impaired in both NR and CA1, but not in mPFC, indicating a failure in transmission of action plans from mPFC to the hippocampus. The findings identify theta-frequency spike-time coordination as a mechanism for gating of information flow in the mPFC-NR-CA1 circuit.