Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Review Article

Frequency-dependent signal transmission and modulation by neuromodulators


Ito,  Hiroshi
Memory and Navigation Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

External Resource
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Ito, H., & Schuman, E. M. (2008). Frequency-dependent signal transmission and modulation by neuromodulators. Front Neurosci, 2(2), 138-144.

Cite as: https://hdl.handle.net/21.11116/0000-0007-F39A-9
The brain uses a strategy of labor division, which may allow it to accomplish more elaborate and complicated tasks, but in turn, imposes a requirement for central control to integrate information among different brain areas. Anatomically, the divergence of long-range neuromodulator projections appears well-suited to coordinate communication between brain areas. Oscillatory brain activity is a prominent feature of neural transmission. Thus, the ability of neuromodulators to modulate signal transmission in a frequency-dependent manner adds an additional level of regulation. Here, we review the significance of frequency-dependent signal modulation in brain function and how a neuronal network can possess such properties. We also describe how a neuromodulator, dopamine, changes frequency-dependent signal transmission, controlling information flow from the entorhinal cortex to the hippocampus.