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Journal Article

Frequency-dependent signal transmission and modulation by neuromodulators


Ito,  Hiroshi
Memory and Navigation Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

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Ito, H., & Schuman, E. M. (2008). Frequency-dependent signal transmission and modulation by neuromodulators. Front Neurosci, 2(2), 138-44. doi:10.3389/neuro.01.027.2008.

Cite as: http://hdl.handle.net/21.11116/0000-0007-F39A-9
The brain uses a strategy of labor division, which may allow it to accomplish more elaborate and complicated tasks, but in turn, imposes a requirement for central control to integrate information among different brain areas. Anatomically, the divergence of long-range neuromodulator projections appears well-suited to coordinate communication between brain areas. Oscillatory brain activity is a prominent feature of neural transmission. Thus, the ability of neuromodulators to modulate signal transmission in a frequency-dependent manner adds an additional level of regulation. Here, we review the significance of frequency-dependent signal modulation in brain function and how a neuronal network can possess such properties. We also describe how a neuromodulator, dopamine, changes frequency-dependent signal transmission, controlling information flow from the entorhinal cortex to the hippocampus.