Modeling developmental patterns of spontaneous activity

Gjorgjieva, Julijana; Eglen, S. J.

doi:10.1016/j.conb.2011.05.015

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Modeling developmental patterns of spontaneous activity

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Gjorgjieva, Julijana
Computation in Neural Circuits Group, Max Planck Institute for Brain Research, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/21684148
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Citation

Gjorgjieva, J., & Eglen, S. J. (2011). Modeling developmental patterns of spontaneous activity. Curr Opin Neurobiol, 21(5), 679-684. doi:10.1016/j.conb.2011.05.015.

Cite as: https://hdl.handle.net/21.11116/0000-0008-0D59-7

Abstract

Spontaneous activity is found in many regions of the developing nervous system; such activity is thought to be instructive for guiding developmental processes. In particular, the developing retina generates correlated patterns of activity known as retinal waves. We review the main theoretical models that have been developed to study the mechanisms for generation and propagation of retinal waves. Much of the progress in this field has been due to the close interaction between experimentalists and theorists in analyzing and modeling spontaneous activity. We conclude by describing spontaneous activity models in other systems and suggestions for future modeling work.