Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis


Schmidt,  Mathias V.
RG Stress Resilience, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Wang, C., Liu, H., Li, K., Wu, Z.-Z., Wu, C., Yu, J.-Y., et al. (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis. NATURE COMMUNICATIONS, 11(1): 6045. doi:10.1038/s41467-020-19874-8.

Cite as: https://hdl.handle.net/21.11116/0000-0008-A579-6
Touch can positively influence cognition and emotion, but the underlying mechanisms remain unclear. Here, we report that tactile experience enrichment improves memory and alleviates anxiety by remodeling neurons along the dorsoventral axis of the dentate gyrus (DG) in adult mice. Tactile enrichment induces differential activation and structural modification of neurons in the dorsal and ventral DG, and increases the presynaptic input from the lateral entorhinal cortex (LEC), which is reciprocally connected with the primary somatosensory cortex (S1), to tactile experience-activated DG neurons. Chemogenetic activation of tactile experience-tagged dorsal and ventral DG neurons enhances memory and reduces anxiety respectively, whereas inactivation of these neurons or S1-innervated LEC neurons abolishes the beneficial effects of tactile enrichment. Moreover, adulthood tactile enrichment attenuates early-life stress-induced memory deficits and anxiety-related behavior. Our findings demonstrate that enriched tactile experience retunes the pathway from S1 to DG and enhances DG neuronal plasticity to modulate cognition and emotion.