Associations of urinary 8-iso-prostaglandin F-2 alpha levels all-cause 
dementia, Alzheimer's disease, and vascular incidence: results from a 
prospective cohort study

Trares, Kira; Gao, Xin; Perna, Laura; Rujescu, Dan; Stocker, Hannah; Moellers, Tobias; Beyreuther, Konrad; Brenner, Hermann; Schoettker, Ben

doi:10.1002/alz.12081

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Associations of urinary 8-iso-prostaglandin F-2 alpha levels all-cause dementia, Alzheimer's disease, and vascular incidence: results from a prospective cohort study

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Perna, Laura
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Trares, K., Gao, X., Perna, L., Rujescu, D., Stocker, H., Moellers, T., et al. (2020). Associations of urinary 8-iso-prostaglandin F-2 alpha levels all-cause dementia, Alzheimer's disease, and vascular incidence: results from a prospective cohort study. ALZHEIMERS & DEMENTIA, 16(5), 804-813. doi:10.1002/alz.12081.

Cite as: https://hdl.handle.net/21.11116/0000-0008-274A-A

Abstract

Introduction: Prospective studies on a potential association of 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha)) levels, a biomarker of lipid peroxidation, with dementia are limited.
Methods: Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF(2 alpha) levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort.
Results: Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF(2 alpha) tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) epsilon 4/epsilon 4 genotype was detected (P = .02). Furthermore, continuously modeled, log-arithmized 8-iso-PGF(2 alpha), levels were statistically significantly associated with all-cause dementia and AD incidence.
Discussion: Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF(2 alpha), levels and the APOE epsilon 4/epsilon 4 genotype showed a considerably increased dementia risk.